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Hemochromatosis - causes, symptoms, diagnosis, treatment, pathology

1399 ratings | 102950 views
What is hemochromatosis? Hemochromatosis is a genetic disorder where the body isn’t able to regulate its iron absorption. Iron levels in the body build up over time and damage the liver as well as other organs, through the generation of free radicals. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
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Text Comments (75)
Helen Ndow (7 days ago)
I wonder, does a black tongue indicate haemochromatosis?
1 Cruzita (8 days ago)
Iron overload? How does consuming a diet high in red meat pertain to iron overload
Shoug Oud (10 days ago)
You didn’t give a good explanation in this video 🤕
Karina K Benitez Diaz (13 days ago)
Hey! i love all your videos!! They help me a lot in getting through med school. I have a suggestion maybe its not a big thing but can you make the same person talk during one video? It is just a suggestion and keep it up bc you have helped me a LOT!!! thanks!!!
SM FLOWER GARDEN (18 days ago)
an excuse for a vampire smut
win don (30 days ago)
so its managed by donating blood?
win don (10 days ago)
+Samantha Newton the water in some areas could be where all the extra metals are coming from. even the cooking utensils. if its not stainless steel then it could be giving off metals in the food
Samantha Newton (10 days ago)
win don ya, or at least that’s how my moms is handled. But they can’t use the blood because of the high levels of iron so they basically just dispose of it
Laura Robinson (1 month ago)
Do NOT skip phlebotomies. As difficult as it may be, it is certainly better than the ICU. Don’t let people assume the worst when it comes to your liver and alcoholism. Any KNOWLEDGEABLE doctor should know the effect hemochromatosis has on your liver. Fight the good fight and in the meantime keep those you love nice and warm.
Laura Robinson (1 month ago)
My boyfriend has hemochromatosis. I miss him so much.
Jamuna (1 month ago)
Type 1 diabetes with late presentation?
Masud ul hasan Misu (1 month ago)
its great
Shahlaa Abdalla (1 month ago)
please make a video about variceal hemorrhage
Only Mrcp (2 months ago)
PLEASE add slightly more information about the HFE regulatory protein and how it regulate absorption and expresion of hepcidin in hepatocyte
Grace Kelly (3 months ago)
I have pernicious anaemia now they are saying I have this to. Is it humanly possible to have both. I have diabetes and erthyrodermic psoriasis too . I feel like I’m dying most days and I’m only 35.
akshay balu (3 months ago)
Can you please make a video on hematopoiesis.
GBoz94 (4 months ago)
I dont understand something- you said the Secondary cause was frequent blood transfusion. I havent had a blood transfusion in my life, and I dont have the primary genetic mutation. So why is my iron saturation high?
GBoz94 (4 months ago)
a lot of this went over my head. Im not so good at chemistry anymore...
robert putt (4 months ago)
Dr Douglas B Kell at the university of Manchester says that ferritin is a by product protein of your organs breaking down due to iron overload. He said that we should not have ferritin in our blood. Very new discovery.
Омар Бус (4 months ago)
Very Nice *****
nikola ognjenovic (4 months ago)
great!!!!
Kathy Lindle (4 months ago)
I was told by my doctor that I had this condition for years but it never showed up before because I had menstrual periods-now that I don't anymore she thinks I need to go to a gastroenterology Dr who told me I need a liver biopsy--why not just donate blood?
carp3tstain (1 month ago)
They are testing for cirrhosis, hemosiderosis (iron overload), and checking levels of iron deposition within the hepatocytes (liver cells). They probably want to detect the specific iron concentrations and potential damage to that organ. They will more than likely do blood work in conjunction with this to get a broader picture of what is going on. I know I'm responding to this 3 month old reply. I hope this helps and all is well with you.
Sophie Bai (5 months ago)
Thank you ,you are really the best
FreedomWorkShop (6 months ago)
4:50 to 5:15 .. you can pinpoint the time where he stopped for a coffee.
Dilianis Arenas (6 months ago)
What program did you use to make the video? :(
random x (6 months ago)
how is ferritin increasing if HFE is defective, meaning that iron cant get into cells???
OnlyMoschops392 (6 months ago)
So, about enterocytes, part of the intestines. Thank you, Osmosis, for teaching me about enterocytes and their role in absorbing nutrients. But how do enterocytes avoid absorbing the majority of the nutrients from the chyme that enters the small intestines?
Jahangir alam (7 months ago)
thanks a lots
mohammed alshareif (8 months ago)
It is absolutely amazing how you can summarize such complicated subjects in such short videos
Bilahari Rejimon (8 months ago)
Thank you, you just helped me with my science project.
Leslie Diaz (8 months ago)
My blood work came back with extremely high iron and I’m really worried. Can this be something else ?
My Channel (8 months ago)
I'm a doctor you have any doubts means feel free to ask me
Leslie Diaz (8 months ago)
veiledviolet I’m being referred to a hematologist/oncologist as well. I hope you’re well too. Hearing what can happen to your body with extreme levels of iron is making me so worried. May I ask what were your symptoms, if you had any?
Karlee R (8 months ago)
Mine did too! Just had my second blood test and my total iron and the percent saturation are both high. My doctor might be sending me to a blood specialist. I don't have any family members with it either so I'm super worried but trying to stay positive. I hope you get everything figured out.
kheang Panda (9 months ago)
How much ferittin will make to be hemochromatosis ?
mohammad sahyouni (9 months ago)
Great , Good work guys
Osmosis (9 months ago)
+mohammad sahyouni thanks!
Sam Stout (9 months ago)
I've got a very high level of iron in my body and the doctors say my liver is off the charts I thought I had this but I'm really pale what could it be?
Leslie Diaz (8 months ago)
fuque yu this cuts down your life time ?? 😩
Lee Romeo (10 months ago)
Clear as a crystal!
Hebh Ahmed (11 months ago)
Great explanation 👏👏👏👏👏👏
Abraham Matar (11 months ago)
❤️
Deezildennis (11 months ago)
I found out i had this a few years back. Dr's found a enlarged liver and thought I was a alcoholic. After telling them I could literally count on my hands and toes how many drinks I had over my life I was diagnosed with this. Took me over a year to get ferretin levels down to where i could just start doing phlebotomy as occasional maintenance. Screwed me up big time.
Carrie Fawcett (10 days ago)
How old were you at diagnosis , just curious
Alexander Lewis (9 months ago)
What number was your iron level back then, before you got it under control? If you don't mind me asking. Thanks in advance.
Nicolas Gonzalez Medina (11 months ago)
So what is the difference between hemochromatosis and hemosiderosis? hemosiderosis dont produce celular damage right?
Altaf Ali Naushad (6 months ago)
Nicolas Gonzalez Medina it’s just excess iron being deposited in tissues as hemosiderin pigment. Can happen in any of the iron overload states they mentioned.
V. S. (1 year ago)
Comodi i sottotitoli in italiano, non presenti in tutti i video, ma comunque fantastici
maya m (1 year ago)
Extremely happy to have discovered this channel! You guys are gonna be a great help in my STEP 2 CK exams as I have an incredibly weak attention span lol
mechanic1756 (1 year ago)
Free radicals are essentials in the did process . Good explanation . Thank you .
Awesome ❣️❣️
Pooja sivakumar (1 year ago)
plz do a video on cardiac arrest!!
rising rebel (1 year ago)
Thanks for all of your videos. Great effort and super explanation. I have a request. Please include gynaecological illnesses in your future video list. 😇
Alexa Wilcox (1 year ago)
Greeetings from Cuba! Hola!!
FrankProgramming03 (1 year ago)
Make a video on Roemheld syndrome
SCOTT DAE HYUN KIM (1 year ago)
I wish I knew these finest lectures before i took a test............
George Badia (4 months ago)
lol
elham alqattesh (1 year ago)
Frequent blood transfusions may cause hemochromatosis because the amount of iron released after this blood is broken down, why that doesn't happen when someone's own blood broke down?!
Kabutar111 (1 year ago)
the reason is AMOUNT , as patient which require regular transfusions have much higher amount of Fe in body generated as compared to normal person where body can reutilise iron generated from breakdown of old rbc to make new
Anasuya Mukherjee (1 year ago)
elham alqattesh transfused blood per se is not causing the damage. As they have told, damage is due to the Excess Iron, whose source may be either the Transfused blood or excess absorption due to some genetic mutation. A normal person can excrete only up to 1 mg of iron through the various routes, as they have told in the initial part of the video, leaving the externally administered iron(I,e. the blood), to gradually accumulate over a long period of time. The oxidative damage due to this excess Iron is what causes the disease. A normally functioning person will not have this extra iron accumulation, coz his intake and output will balance each other.
elham alqattesh (1 year ago)
Anasuya Mukherjee 👍🏻👍🏻thnx But the question is why the damage of transfused blood causes hemochromatosis while the the damage of own blood don't ?
Anasuya Mukherjee (1 year ago)
elham alqattesh Hence, there's this extra iron accumulation, once the TRANSFUSED cells too get senescent and are also broken down. Further transfusions, again to maintain the CIRCULATING POOL OF RBCs just adds on to that! Hope, it helps ! Sorry, for this lengthy banter!☺
Anasuya Mukherjee (1 year ago)
elham alqattesh Additionally, we give blood transfusions to maintain the CIRCULATING RBC'S IN THE BLOOD THAT ARE NEEDED TO CARRY OXYGEN TO THE TISSUES, as; WHATEVER THE BODY ITSELF PRODUCED NEVER REACHED THE CIRCULATING POOL AND WAS DEGRADED IN THE MARROW ONLY.
anant bhavsar (1 year ago)
thanks alot again !!
Muhammad Tauqeer (1 year ago)
Otosclerosis and Meniere's disease, please.
Humberto Mancilla (1 year ago)
Guillain-Barre syndrome please! Grettings from México
Teenssj2 (1 year ago)
LOOOOVING IT
Fatima Azahra (1 year ago)
Thann you 😻😻😻😻
léo thomas (1 year ago)
I've just studied that subject in class! Good work!
Osmosis (1 year ago)
We've updated this video! We've added a few sections, and corrected a couple of minor errors.
akshay balu (3 months ago)
Osmosis I need your help to study hematopoiesis. Will you help me?
Sandra Salameh (9 months ago)
thank you very much for those videos you are really helping us .. please keep going ..
Udayananda Bandara (1 year ago)
excellent teaching style

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