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Non-alcoholic fatty liver disease (NAFLD) - causes, symptoms, diagnosis, treatment, pathology

1611 ratings | 138384 views
What is non-alcoholic fatty liver disease (NAFLD)? NAFLD is a type of liver disease where fat is deposited (steatosis) in the liver due to non-alcohol-related reasons. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
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Text Comments (123)
whatever00 (27 days ago)
I'm watching this at 1 am and I just lost it with the fat guy running to catch a tomato 😂. Thank you for the video and for making me laugh so much!
Olia Wan (1 month ago)
.i don't understand how insulin resistance cause storage of fat in liver and decreased fatty oxidation
Ingit Scoob (2 months ago)
Thanks
Gex Gex Gx (3 months ago)
اريده من غير ترجمه
Dinesh Raja (3 months ago)
Hey thank you so much! You were simple and amazing! May God bless you 😁✌️
Theist Medic (3 months ago)
You are a miracle
Δάφνη Κόλλια (3 months ago)
oh my god the meow of the cat in 5:31 scared me i thought it was my cat that wanted something. Also this video is awesome, keep it up!!
burymedeep 2093 (4 months ago)
Lay off the beer and pizza
Ibi Banun (5 months ago)
Hey Osmosis, love the vids. Correction to metabolic syndrome criteria, I believe you look for low HDL, and not hyperlipidemia. Unless I'm confusing something. Let me know.
They call me Carl (5 months ago)
So what the heck is a "healthy diet" and why didn't you tell us this most important information? It seems like it is impossible to know anymore!
abuwadie3 (7 months ago)
What are your qualifications to speak on these topics? Please list your sources. I’m coming with good intent. I enjoy your videos. But want info on your credentials
Irtaza Rehman Lectures (7 months ago)
Really helpfull
MultiMusik4 (8 months ago)
Dont eat sugar!!!!
DR ABHINAV GOLLA (8 months ago)
Great vdos guys.. please do make a playlist on all chromosomes each individually???? .44 autosomes and 2sex chromosomes and their importance .
Rand Wulf (8 months ago)
Instead of pumping yourself full of medications to "control" blood sugar levels, just stop eating foods high in sugar and low in fiber, then slowly start increasing your daily physical activity. It's really sad that people are so lazy and addicted to sugar they are killing themselves and think medications are going to make it all better, though that mindset is great for the pharmaceutical and sickcare industry bank accounts.
Mr. Infinity (8 months ago)
Please reply osmosis......i don't understand how insulin resistance cause storage of fat in liver and decreased fatty oxidation
SnipeShotGG (1 month ago)
Insulin causes the uptake of glucose from blood to cells; once insulin-resistant receptor appears, the hepatocytes takes in fats as an alternative to the the glucose
Please add turkish subtitles i cannot understand english very well
Lobby Fisher (9 months ago)
I m eating healthly and I exercise but I can't reverse my fatty liver
Walter White (10 months ago)
I am suffering from NASH ,, i am in early stage!..
Rand Wulf (8 months ago)
The great news is you can mostly, if not entirely, reverse NASH by eating better foods (high fiber, low carb) and start increasing your daily physical activity. The liver is a remarkable organ, and it can slowly heal itself, unlike some other organs. Oh, and NO ALCOHOL! Its pure poison for the liver.
ayushi raz (10 months ago)
Osmosis your vedios are just awesome 😻 they are so helpful for cleaning pathology concepts! I have downloaded osmosis app though ! The thing i am encountering is a yellow lock 🔐 appearing on few vedios of each system!! Wanted to knw th reason and what could be done for it ! I also didn’t find any subscription option in that !!
Buro Dadu (11 months ago)
this channel is too valuable to share with friends.
Adam Richardson (3 months ago)
If you want to learn how to get rid of your fatty liver then visit this website here: HootLiver.xyz
norma villegas (3 months ago)
Many thanks, been searching for "what causes fatty deposits around the liver" for a while now, and I think this has helped. You ever tried - Jeyebastian Venlena Blaster - (do a google search ) ? Ive heard some decent things about it and my partner got amazing success with it.
Corey Brown (8 months ago)
not to share?
Barry Fennell (11 months ago)
take medication to control blood glucose? Just stop eating carbohydrates. You don't realize how sick you are with until you fix your diet.
Rand Wulf (8 months ago)
Yeah, I 99% support this video but not the ridiculous notion of taking medications so you can keep gorging on foods high in sugar, low (or no) fiber. Ugh. Otherwise, brilliant video.
Aseni De silva (11 months ago)
We did a study to find the association between Nonalcoholic fatty liver disease (NAFLD) and incidence of diabetes mellitus. https://goo.gl/VnuU1H. There we found that, subjects with ultrasonically diagnosed NAFLD have an increased risk of developing diabetes mellitus.
Jamie Slagle (1 year ago)
at around the 5:30 mark... is that a cat meowing??
Karolina Kuls (7 months ago)
to me its a cat :P but whyy ^^
Osmosis (1 year ago)
If I recall, it was a dramatic "no" sound effect with a heightened pitch. A cat scream would have been funny, though.
You guys are soooo amazing , 💪🏼 bless you
Osmosis (1 year ago)
Thank you, Dr. ACH TEE! We're happy you’re finding the videos useful!  If you haven't yet checked out our educational platform we’re working hard to be a one-stop shop for educating future clinicians. We have unreleased videos, thousands of flashcards and board-style practice questions, study workspaces, and daily study scheduling tools to help you learn, retain and apply medical knowledge. Check us out here! http://bit.ly/2ut5ZEJ.
Deva Guru (1 year ago)
Types of tumor too
Deva Guru (1 year ago)
Video about Portal hypertension Plz
Osmosis (1 year ago)
We will eventually, Deva! In the meantime, you can vote for upcoming videos, see all of our unreleased videos and access tens of thousands of flashcards and quiz questions by becoming an Osmosis Prime subscriber. You can sign up for a free trial at http://bit.ly/2ut5ZEJ.
PARTHIBAN G (1 year ago)
This is really awsome .. i nowadays started watching videos rather than books .. ur videos r simply superb... Keep it up ..!!
Osmosis (1 year ago)
Thanks, Parthiban! That's the plan!If you’re interested in getting early access to our videos check us out on Facebook: http://bit.ly/2u35D6J, or, even better, get exclusive access to dozens of our unreleased videos now at our website: http://bit.ly/2ut5ZEJ.
Adelyne Huynh (1 year ago)
Thank you for another great video! Also, I have to say, that animation around 5:32 is too adorable not to mention
Osmosis (1 year ago)
Thanks, Adelyne! Yeah, I probably spent too much time on that gag, but I'm happy you liked it! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on YouTube? Check it out here:   http://bit.ly/2u35D6J
Rommy A. Coutelin (1 year ago)
Very informative, yet simple video. Well done! keep up the good work!
Osmosis (1 year ago)
Thanks for the kind words, Rommy! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on YouTube? Check it out here:   http://bit.ly/2u35D6J
zkskduel (1 year ago)
thank you for training the mind in concepts. it makes studying fun. keep it up osmosis
zkskduel (1 year ago)
I would check it out. it's been on my list
Osmosis (1 year ago)
Thanks for the kind words, zkskduel! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: http://bit.ly/2ut5ZEJ
Joe Lahoud (1 year ago)
Brilliant and informative video, thank you so much!
Osmosis (1 year ago)
Thank you for watching Captain Picard! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on YouTube? Check it out here:   http://bit.ly/2u35D6J
Katie Kaboom (1 year ago)
What about if the liver enzymes are high due to years of medication for kidney transplant?
Yuriy Mazin (1 year ago)
@osmosis is alcoholic hepatitis the same as alcoholic esteatohepatitis? thx
Maryam Eghbaljou (1 year ago)
you are awesome. I review medicine with you after almost 20 years of my graduation. It was very helpful for a quick review.
Sharna Clarke (1 year ago)
You sound different 😱
Tomáš Faltáni (1 year ago)
He speaks really fast in this one :(
Lalhminghlua sailo (1 year ago)
Can you do lipoma please?
kiratpreet dhillon (1 year ago)
Insulin inhibits b-oxidation and increases fatty acid, so the converse should take place in case of resistance, right?
kiratpreet dhillon (1 year ago)
yea..makes sense..thank you. @anasuya
Anasuya Mukherjee (1 year ago)
kiratpreet dhillon And also, beta oxidation of fatty acids will increase the intracellular levels of NADPH/NADH. This will effectively turn off the TCA cycle; shunting the Oxaloacetate to gluconeogenesis and the Acetyl CoA to either ketogenesis or reform fatty acids (the high NADH/NAD ratio)😐
Anasuya Mukherjee (1 year ago)
Hey! This is purely out of my own understanding to find an answer to your question as it left me thinking about it. Hope, it helps you.
Anasuya Mukherjee (1 year ago)
Insulin resistance > excess insulin release> more expression of lipoprotein lipase in the lumen of tissue capillaries> more breakdown of TAG carrying chylomicrons or VLDL (either from intestine or liver)> more mobilisation of free fatty acids> will ultimately be channeled to liver in case peripheral tissues don't require them .
Anasuya Mukherjee (1 year ago)
Insulin inhibits lipolysis of Triacylglycerol stores in adipose tissue. If there's insulin resistance, then lipolysis of the TAG in adipose tissue is uninhibited. These free fatty acids (derived from TAG) travel to peripheral tissues for uptake and breakdown ,including liver. Excess influx of fatty acids into liver, causes these to accumulate( overwhelms the liver's oxidative capacity).
Hanaa khudair (1 year ago)
thanx alot for your efforts .but i ask if there's any written summary for these videos ?o
Osmosis (1 year ago)
Not yet, but we have something coming this summer!
Priyanka Tiwari (1 year ago)
thanks a lot....very nice videos. ..keep up the good work. ..god bless
DocHemulin (1 year ago)
For the definition of the metabolic syndrome there needs to be hyperglycemia and not necessarily diabetes-prediabetes is sufficient for the criteria.
Dr. Hareethha (1 year ago)
do you have a video of inborn errors of metabolism organ function test...????
Nasmah Natafji (1 year ago)
you are doing a great job!
Altun (1 year ago)
You should use the term 'dislipidemia' instead of hyperlipidemia. Because HDL levels not increased but decreased. Dislipidemia more accurate :)
suga pop (1 year ago)
lovin it....
mechanic1756 (1 year ago)
Ok,  Thank you for posting and corrections  .What can be done to stop the process on the reversible area  and not to progress to fibrosis?. When is the time for a biopsy ? Are NAFLD patients candidates for Statins as part of Metabolic syndrome treatment ?
abuwadie3 (7 months ago)
mechanic1756 yes they are. Depending on the elevation of liver enzymes. I would consider a fibroscan before a biopsy.
zin zineb (1 year ago)
a vidéo about ulcer and its complications pleaaase 🙆🙆
Osmosis (1 year ago)
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
DR SULTAN SAUDAGAR (1 year ago)
sir your videos are awesome......there are some channels they are stealing your videos ....keep watch on them....
DR SULTAN SAUDAGAR (1 year ago)
Osmosis check ur inbox
Osmosis (1 year ago)
No problem, you can just send us a message at hi@osmosis.org
DR SULTAN SAUDAGAR (1 year ago)
provide personal email....i will tell ...bcuz im also a youtuber and i dont want to spoil my channel...by some antisocial element
Osmosis (1 year ago)
Can you let us know which channels?
Vikram Lodhi (1 year ago)
plz make a video of peptic ulcer and malabsorption syndrome and tumors of git
Osmosis (1 year ago)
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
Quốc Tuấn Phạm (1 year ago)
Could you add the Official English Subtitle for this video ? Thank you
Osmosis (1 year ago)
Woops, yep, done.
shashank reddy (1 year ago)
can you make a video on portal hypertension
Kevin K (7 months ago)
shashank reddy This is just superb, been searching for "can your liver hurt" for a while now, and I think this has helped. You ever tried - Bachalaswin Better Body Rule - (do a search on google ) ? Ive heard some unbelievable things about it and my buddy got amazing results with it.
prettycoder (8 months ago)
Thanks for the Video! Apologies for chiming in, I am interested in your opinion. Have you considered - Millawdon Fatty Liver Trick (search on google)? It is a great one of a kind product for learn how to reverse fatty liver without the hard work. Ive heard some amazing things about it and my close friend Aubrey at last got astronomical success with it.
Hytham salah (1 year ago)
Could you do tutorial for bronchiectasis ?
Osmosis (1 year ago)
We will eventually! You can vote for upcoming topics by becoming a Patreon subscriber. www.patreon.com/osmosis
Sodium Hypochlorite (1 year ago)
Could you guys do osteoperosis or crippling depression next?
Osmosis (1 year ago)
We will eventually! You can vote for upcoming topics by becoming a Patreon subscriber. www.patreon.com/osmosis
Sodium Hypochlorite (1 year ago)
Osmosis How bout that osteoperosis?
Osmosis (1 year ago)
Depression: https://www.youtube.com/watch?v=QhukM33VLgo
Spookdog (1 year ago)
idk if you take suggestions but I looked through your channel and couldn't find any videos on complex PTSD, could you make a video on it? I haven't found many good videos on it and I really think it should be more known.
Lum Ang But (1 year ago)
Karashoo Silverclaw Do you have the videos of phamagolgy or treatment methods for each disease with medicines? Thank you for all you do.
Spookdog (1 year ago)
+Osmosis okay, thanks!
Osmosis (1 year ago)
Gotcha - you can vote on upcoming topics by joining patreon: https://www.patreon.com/osmosis
Spookdog (1 year ago)
+Osmosis I've seen it, but I'm talking about specifically CPTSD, which is very different from normal PTSD in some ways.
Osmosis (1 year ago)
Here's our video on PTSD: https://www.youtube.com/watch?v=hzSx4rMyVjI
Osmosis (1 year ago)
We've updated this video! There was some issues with our AST and ALT numbers, so we've updated our phrasing: Because hepatocytes are being destroyed, there can be an increase in liver enzymes such as aspartate transaminase (AST) and alanine transaminase (ALT). Classically, progression of steatosis to steatohepatitis and then to cirrhosis causes an increase in the ALT and sometimes AST. In contrast, alcoholic liver injury generally causes the a big increase in AST and a more modest increase in ALT giving a AST:ALT ratio generally > 2.
]M (7 months ago)
This was great, thanks, been searching for "liver diseases symptoms and treatment" for a while now, and I think this has helped. Have you ever come across - Bachalaswin Better Body Rule - (search on google ) ? Ive heard some incredible things about it and my work buddy got excellent results with it.
RA (7 months ago)
This was great, thanks, I been tryin to find out about "liver failure diet" for a while now, and I think this has helped. Have you ever come across - Bachalaswin Better Body Rule - (just google it ) ? Ive heard some extraordinary things about it and my neighbour got excellent results with it.
Najib Casa (7 months ago)
This is just superb, I been tryin to find out about "can a fatty liver heal" for a while now, and I think this has helped. You ever tried - Bachalaswin Better Body Rule - (search on google ) ? Ive heard some awesome things about it and my neighbour got amazing results with it.
REM 2 (7 months ago)
Just wonderful, I've been looking for "muscle inflammation" for a while now, and I think this has helped. Have you ever come across - Bachalaswin Better Body Rule - (Have a quick look on google cant remember the place now ) ? Ive heard some amazing things about it and my cousin got cool success with it.
GC 73 (10 months ago)
Many thanks, I been tryin to find out about "alcoholic fatty liver and diabetes" for a while now, and I think this has helped. Have you heard people talk about - Fackenzieron Fatigue Filtration - (Have a quick look on google cant remember the place now ) ? Ive heard some incredible things about it and my brother in law got excellent success with it.

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