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Resin Drugs: How to Lower Cholesterol
 
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Introduction to how resin drugs (ex: cholestyramine, colestipol) work to reduce cholesterol in the body. Disclaimers: -The information in this video only represents the knowledge of the individual(s) depicted in it and not those of any institution or other individual(s). -The authors would love to hear your feedback, but they are not responsible for any errors or liabilities held within these videos.
Views: 9541 Med School Made Easy
Pharmacology - DRUGS FOR HYPERLIPIDEMIA (MADE EASY)
 
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Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: basic pathophysiology of hyperlipidemia, lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, vascular inflammation. Mechanism of action of antihyperlipidemic drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitor, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin, niacin, fenofibrate, gemfibrozil, colesevelam, colestipol, cholestyramine, ezetimibe, evolocumab, alirocumab, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), icosapent ethyl, fish oil.
Views: 121122 Speed Pharmacology
Cholestyramine Meaning
 
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Video shows what cholestyramine means. A drug that lowers the level of cholesterol in the blood by sequestering bile acids.. Cholestyramine Meaning. How to pronounce, definition audio dictionary. How to say cholestyramine. Powered by MaryTTS, Wiktionary
Views: 992 SDictionary
Niacin effects on Cholesterol (Mechanism of Action)
 
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See Text below for more information about Niacin and its effects on Lipids overall. Niacin (or Nicotinic Acid) is a form of vitamin B3. Niacin is one of the essential nutrients for the human body. Niacin deficiency can cause pellagra, while insufficient niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. A recommended daily allowance of niacin would be 2–12 mg/day for children, 14 mg/day for women, 16 mg/day for men, and 18 mg/day for pregnant or breast-feeding women. Niacin in much higher doses than those recommended as daily dietary allowance is a potent agent against Dyslipidaemia. In doses as high as 1.500 - 2.000mg is proven to reduce LDL (bad) cholesterol by 20%, increase HDL (good) Cholesterol by 30%, and also reduce Triglycerides by almost 40%. It is also proven to reduce the atherogenic fraction of LDL: Lp(a), and apolipoprotein Apo-B (which is the carrier of lipids in LDL-C). Two large studies have been conducted with these doses of Niacin with patients under treatment with Statins. (AIM-HIGH & HPS2-THRIVE). These studies concluded that there is no added cardiovascular benefit by concomitant use of high doses of Niacin along with statin treatment, when LDL-C levels are already very low. It seems though that Niacin treatment is effective in patients not treated with statins. Niacin in such high doses can cause Flushing. Another form of vitamin B3 is Nicotinamide, but only Niacin has been found to have this strong effect on dyslipidaemia.
Views: 7775 Tagouz
Cholestyramine
 
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Cholestyramine or colestyramine (Questran, Questran Light, Cholybar, Olestyr) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer. Cholestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, which are then excreted in the feces. As a result of this loss of bile acids, more plasma cholesterol is converted to bile acids in the liver to normalize levels. This conversion of cholesterol into bile acids lowers plasma cholesterol levels. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video
Views: 3574 Audiopedia
Bile Acid Resins, Cholesterol Absorption Blockers & Fibrates
 
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http://usmlefasttrack.com/?p=437 Cholestyramine, Colestipol, Colesevelam, Ezetimibe, Gemfibrozil, Clofibrate, Bezafibrate, Fenofibrate, prevent, reabsorption, bile acids, cholestrol, bad taste, gi discomfort, gallstones, First Aid, for, USMLE, Step 1, wiki, define, wikipedia, prevent, cholesterol, intestinal, brush, border, LFT, diarrhea, Upregulate LPL, Triglycerides, myositis, hepatotoxicity, cholesterol gallstone,
Views: 7226 USMLEFastTrack
Statins, Fibrates, Niacin, etc. - Easy Pharm for USMLE Step 1
 
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This animated video covers statins, fibrates, niacin, bile resins, and ezetimibe. We will discuss mechanisms of action, which part of the lipid profile is affected by each drug, and common side effects. Pharm450 is the easiest way to study pharmacology for USMLE Step 1. We've packed an entire course on medical pharmacology into a set of entertaining videos that leverage your visual, spatial, and emotional memory so you learn faster and retain more. Find more videos online: http://pharm450.com http://facebook.com/Pharm450 http://twitter.com/Pharm450
Views: 185255 Pharm 450
Biotoxin Part V:  Getting Rid of Biotoxins with Cholestyramine
 
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This video is about Biotoxin Part 5; Getting Rid of Biotoxins with Cholestyramine
Views: 770 John Whitcomb
How does cholestyramine powder work
 
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How does cholestyramine powder work - Find out more explanation for : 'How does cholestyramine powder work' only from this channel. Information Source: google
Views: 116 Arif Hidayat
Lipid Lowering Agents
 
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Understand the antihyperlipidemic agents once and all! In this quick board review lecture I'm gonna cover the anti-hyperlipidemic agents and that includes the following groups. The HMG-CoA reductase inhibitors, the fibrates, niacin, bile acid sequestrants and cholesterol absorption inhibitors. Let's get started. The HMG-CoA reductase inhibitors are a very important group of drugs. Five out of five you've got to know these drugs for your exams. The more common name for these drugs is the statins. However, the mechanism of action is actually found in the first name. They are reversible and competitive inhibitors of HMG-CoA reductase. That is a very important rate-limiting enzyme in the pathway that produces cholesterol in our liver de novo. On the right I have a picture to explain this but I'm gonna break it down and walk through the steps. Starting with acetyl-CoA. Acetyl-CoA is an important molecule in biologic reactions and it plays an important part in the synthesis of cholesterol. Acetyl-CoA is basically an acetyl group that is linked to coenzyme A. Let me just shorten coenzyme A to just CoA. In that first step on our list below you can see that if we combined two acetyl-CoAs together through the enzyme thiolase we get a molecule called acetoacetyl-CoA. If we then take that molecule and add another acetyl-CoA through the enzyme HMG-CoA synthase we have HMG-CoA, and this is where the statins work. The statins block the next step. What's supposed to happen is that this HMG-CoA is supposed to be reduced to mevalonic acid. Again, the statins block this from happening and therefore ultimately inhibit or decrease the production of cholesterol de novo in the liver. Major side effects for the statins include hepatic toxicity, however, while this can be severe, only about one to two people per 10,000 patient years have this problem. What's more common by far is myositis or myalgias. It is very common that your patients could complain of muscle aches while on this medication. And in severe cases, they could have Rhabdomyolysis from it. As for examples for the statins, we have these four here. Rosuvastatin, atorvastatin, simvastatin and lovastatin and I organized this list in this way on purpose. On the right side of this little list are the equivalencies. Rosuvastatin is the strongest of these four statins with an equivalency of 1.0. Lovastatin is the weakest of these statins with an equivalency of eight. In other words you would need theoretically and it doesn't work out exactly but you would need about eight milligrams of lovastatin to equal the effect that you get with one milligram of rosuvastatin. And finally if you really want to impress your preceptors look up the ASTEROID Trial which was done in 2006. It showed that patients who are treated with 40 milligrams of rosuvastatin actually had a regression of their atherosclerotic plaques at a two-year follow-up. Moving on, now the fibrates. These drugs are pretty easy to pick out in a group because they end in -fibrate or -fibrozil. These drugs are often given in combination with the statins because there's not a lot of good evidence to support using them alone. As for their mechanism of action, they act by stimulating or activating the peroxisome proliferator-activated receptor subtype alpha, or abbreviated PPAR alpha. Don't confuse this with PPAR gamma. The PPAR gamma is stimulated by the related class of drugs, the thiazolidinediones which are used for diabetes. Naturally in the body, these PPAR alpha receptors are found on the cell nucleus. They are used in the regulation of carbohydrates and fatty acids. When we stimulate these receptors with the fibrates we change that metabolism and this works by having the drug bind the receptor which makes the receptors move into the nucleus. Once in the nucleus, the PPAR alpha binds another receptor called the retinoid X receptor and that complex binds DNA on sequences that are called peroxisome proliferator hormone response elements. These response elements are responsible for the expression of proteins that are involved in the metabolism of fatty acids and triacylglycerides. For example, you would see an increase in the expression of lipoprotein lipase. This would increase the metabolism of triacylglycerides. Also it would increase the expression of apolipoprotein A1 and apolipoprotein A2. Those are lipoproteins that are important in the structure of an HDL particle. The side effects for the fibrates include GI upset, this is really common. You very well could see your patient complain of a stomach ache on the fibrates.
Views: 42704 Med Immersion
What does cholestyramine mean?
 
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What does cholestyramine mean? A spoken definition of cholestyramine. Intro Sound: Typewriter - Tamskp Licensed under CC:BA 3.0 Outro Music: Groove Groove - Kevin MacLeod (incompetech.com) Licensed under CC:BA 3.0 Intro/Outro Photo: The best days are not planned - Marcus Hansson Licensed under CC-BY-2.0 Book Image: Open Book template PSD - DougitDesign Licensed under CC:BA 3.0 Text derived from: http://en.wiktionary.org/wiki/cholestyramine Text to Speech powered by TTS-API.COM
Cholestyramine - Colestiramina
 
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Views: 15778 David Ostrovsky
Cholestyramine uses
 
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Cholestyramine 6286
Views: 983 Piyush Soni
Cholestyramine Colestyramine taken for first time.
 
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Taking this for a washout to clear leflunomide out my body. Two 4g sachets three times a day.
Views: 3187 John Gallacher
Cholestyramine diarrhea
 
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Bowtrol Colon Health Support was developed for people with sensitive digestion, particularly a sensitive colon.
Views: 2463 John Health
How bile acid work?
 
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Please Rate, Leave Comments & Subscribe Me :) http://bodyologymassagecourses.co.uk/forum/ The Virtual Campus is a free learning and networking website about massage. Join our network, create your profile, meet like-minded people and engage in a group or a free course. Bodyology students benefit from extra Elearning recourses. Facebook: http://www.facebook.com/BodyologyMassageSchool?v=wall YouTube: http://www.youtube.com/user/Bodyology?feature=mhee Twitter: https://twitter.com/#!/Bodyology LinkedIn: http://www.linkedin.com/pub/dror-steiner/8/947/763 Our Website for more details: http://bodyologymassagecourses.co.uk/
LOWER CHOLESTEROL WITHOUT PILLS!!
 
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Follow me on these as well! Thanks! https://www.facebook.com/profile.php?id=100005166796282 https://twitter.com/Questionurfood http://instagram.com/questionyourfood/ An easy way to drastically lower your cholesterol without the use of drugs or pills! The drug companies don't want you to know about this, as they could stand to lose a lot of money. Boo hoo! Maybe you've heard of or take Statins Altoprev lovastatin Crestor rosuvastatin Lescol fluvastatin Lipitor atorvastatin Mevacor lovastatin Pravachol pravastatin Zocor simvastatin Colestid colestipol Questran cholestyramine/ sucrose Welchol colesevelam Zetia ezetimibe Vytorin ezetimibe-simvastatin Lofibra fenofibrate Lopid gemfibrozil TriCor fenofibrate Niaspan (prescription niacin) Advicor niacin-lovastatin bile acid binding resins, cholesterol absorption inhibitor, fibrates Lovaza prescription omega-3 fatty acid supplement Vascepa Icosapent ethyl. There are a lot of different pills, medications, and drugs. I'll show you my blood work panel and my ldl, low-density lipoprotein, hdl, high-density lipoprotein, cholesterol, triglycerides and my cholesterol ratio risk.
Views: 4160 Question Your Food
Bile acid malabsorption
 
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Bile acid malabsorption, known also as Bile acid diarrhea, is a cause of chronic diarrhea. It has also been called Bile acid-induced diarrhea, Cholerheic or Choleretic enteropathy and Bile salt malabsorption. It can result from malabsorption secondary to gastro-intestinal disease, or be a primary disorder, associated with excessive bile acid production. Treatment with bile acid sequestrants is often effective. This video is targeted to blind users. Attribution: Article text available under CC-BY-SA Creative Commons image source in video
Views: 5458 Audiopedia
Questran/cholestyramine.. Blurred wked/blurred Day
 
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"The purpose of this channel is to spread awareness of lyme and many other chronic illnesses,that this is real, and not in our head. We are here to join forces to be heard, by a Goverment that chooses to ignore us.
Views: 291 Lyme N Rmsf Warrior
Cholestyramine detox for Lyme and mold exposure
 
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Cholestyramine is a binder prescribed for Lyme and mold exposure to flush out toxins. It may help with symptoms of toxin overload including nerve pain when toxins irritate the nerves. Also recommended to help flush out histamine when there is an overload.
Views: 1503 E Woodson
Antihyperlipidemic drugs animation: Fibrates
 
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Fibrates are group of hyperlipidemic drugs with wide range of actions. Drug for hyperlipidemia. It decreases LDL synthesis, Increases fatty acid degradation. Decreases TAG formation. Additionally it enhance synthesis of apoproteins AI and AII which result in enhancement of HDL synthesis
Toxin Binding with Cholestyramine & Colsevelam in CIRS
 
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Toxins involved in CIRS are processed by the immune system. They pass into the liver and are excreted into the bile. Bile is re-absorbed in the intestine which can bring toxins back to the liver and keep them in the body. Bile-binding resins can prevent this re-absorption allowing toxins to be excreted into the stool.
Views: 763 Raymond Oenbrink
Medical vocabulary: What does Cholestyramine Resin mean
 
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What does Cholestyramine Resin mean in English?
Views: 81 botcaster inc. bot
Cholesterol Lowering Agents - Where they work
 
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http://usmlefasttrack.com/?p=438 Cholestyramine, Colestipol, Colesevelam, Ezetimibe, Gemfibrozil, Clofibrate, Bezafibrate, Fenofibrate, prevent, reabsorption, bile acids, cholestrol, bad taste, gi discomfort, gallstones, First Aid, for, USMLE, Step 1, wiki, define, wikipedia, prevent, cholesterol, intestinal, brush, border, LFT, diarrhea, Upregulate LPL, Triglycerides, myositis, hepatotoxicity, cholesterol gallstone, lovastatin, pravastatin, simvastatin, atorvastatin, rosuvastatin, LDL, HDL, triglycerides, mevolanate, precursor, cholestrol, hepatotoxicity, LFT, rhabdomyolysis, First Aid, for, USMLE, Step 1, wiki, define, wikipedia, Inhibits lipolysis, reduce VLDL, red, flushed face, asprin, hyperglycemia, acanthosis nigricans, hyperuricemia, exacerbates, gout,
Views: 1400 USMLEFastTrack
Resin, bile acid - Medical Definition and Pronunciation
 
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Resin, bile acid Resin, bile acid: Bile acid resins are substances that bind in the intestines with bile acids that contain cholesterol and are then eliminated in the stool. The major effect of bile acid resins is to lower LDL-cholesterol by about 10 to 20 percent. Small doses of resins can produce useful reductions in LDL-cholesterol. Bile acid resins are sometimes prescribed with a statin for patients with heart disease to increase cholesterol reduction. When these two drugs are combined, their effects are added together to lower LDL-cholesterol by over 40 percent. Cholestyramine (brand name: QUESTRAN) and colestipol (COLESTID) are the two main bile acid resins currently available. These two drugs are available as powders or tablets. They are not absorbed from the gastrointestinal tract and decades of experience with the resins indicate that their long-term use is safe. Bile acid resin powders must be mixed with water or fruit juice and taken once or twice (rarely three times) daily with meals. Tablets must be taken with large amounts of fluids to avoid gastrointestinal symptoms. Resin therapy may produce a variety of symptoms including constipation, bloating, nausea, and gas. The bile acid resins are not prescribed as the sole medicine to lower your cholesterol if you have high triglycerides or a history of severe constipation. How to pronounce Resin, bile acid definition of Resin, bile acid audio dictionary How to say Resin, bile acid What is the meaning of Resin, bile acid Pronounce Resin, bile acid Medical dictionary Medical definition of Resin, bile acid
USMLE: WMedical Video Lectures Pharmacology about Cholestyramine by UsmleTeam
 
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Views: 2546 allornonelaw
Can cholestyramine be used to treat diarrhea
 
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Can cholestyramine be used to treat diarrhea - Find out more explanation for : 'Can cholestyramine be used to treat diarrhea' only from this channel. Information Source: google
Views: 76 Gunar gunar
Bile acid resin - Medical Meaning and Pronunciation
 
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Bile acid resin Bile acid resin: Bile acid resins are substances that bind in the intestines with bile acids that contain cholesterol and are then eliminated in the stool. The major effect of bile acid resins is to lower LDL-cholesterol by about 10 to 20 percent. Small doses of resins can produce useful reductions in LDL-cholesterol. Bile acid resins are sometimes prescribed with a statin for patients with heart disease to increase cholesterol reduction. When these two drugs are combined, their effects are added together to lower LDL-cholesterol by over 40 percent. Cholestyramine (brand name: QUESTRAN) and colestipol (COLESTID) are the two main bile acid resins currently available. These two drugs are available as powders or tablets. They are not absorbed from the gastrointestinal tract and decades of experience with the resins indicate that their long-term use is safe. Bile acid resin powders must be mixed with water or fruit juice and taken once or twice (rarely three times) daily with meals. Tablets must be taken with large amounts of fluids to avoid gastrointestinal symptoms. Resin therapy may produce a variety of symptoms including constipation, bloating, nausea, and gas. The bile acid resins are not prescribed as the sole medicine to lower your cholesterol if you have high triglycerides or a history of severe constipation. How to pronounce Bile acid resin definition of Bile acid resin audio dictionary How to say Bile acid resin What is the meaning of Bile acid resin Pronounce Bile acid resin Medical dictionary Medical definition of Bile acid resin
Views: 56 Medical Dictionary
Take Your Medicine
 
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A short video showing how to take a powdered medicine.
Views: 944 William Graham
What are the side effects of questran
 
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What are the side effects of questran - Find out more explanation for : 'What are the side effects of questran' only from this channel. Information Source: google
Views: 27 elubuntu1a
#05 Cholesterol in the family?
 
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Frank Cooper, Naturopath and Nutritionist, is the author of the book 'Cholesterol and The French Paradox' written for patients with high cholesterol. Frank Cooper has university qualifications in complementary medicine and microbiology, and is qualified to practice as a Naturopath (ND) and as a Nutritionist. His research is on environmental medicine that studies the alignment of our environment (food, water, chemicals, microbes) with chronic disease states including cancer, heart disease and diabetes. Frank is the author of the book Cholesterol and The French Paradox available from www.amazon.com that explains why only 10% of those taking statins (cholesterol-lowering medications) actually derive any benefit, whilst the other 90% gain no benefit at all, but are 'at risk' of liver toxicity and damage, muscle damage, and worst of all -- irreversible mental cognitive impairment.
Views: 250 Frank Cooper
Cholestyramine ma3 Bishoy Abo Hafiza :D
 
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class 2009-2014 :)
Views: 382 CP.SU. CU
What You MUST Know If You Don't Have a Gallbladder
 
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Dr. Berg's Gallbladder Support: https://shop.drberg.com/gallbladder-f... or go to Amazon: http://amzn.to/2fydNKv Take Dr. Berg's Advanced Evaluation Quiz: http://bit.ly/EvalQuiz Your report will then be sent via email analyzing 104 potential symptoms, giving you a much deeper insight into the cause-effect relationship of your body issues. It's free and very enlightening. Dr. Berg talks about what you need to know if you don''t have a gallbladder. The gallbladder is a vital organ that stores and concentrates bile and when it's gone, fat digestion,fat soluble vitamin absorption (vitamin A, D, E, K) can be a problem. This is due to the function of concentration. The gallbladder concentrates bile by 5x - and without this, fat digestion and healthy fat absorption will be deficient. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional and natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government and the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning, published by KB Publishing in January 2011. Dr. Berg trains chiropractors, physicians and allied healthcare practitioners in his methods, and to date he has trained over 2,500 healthcare professionals. He has been an active member of the Endocrinology Society, and has worked as a past part-time adjunct professor at Howard University. DR. BERG'S VIDEO BLOG: http://www.drberg.com/blog FACEBOOK: http://www.facebook.com/DrEricBerg TWITTER: http://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericbe... ABOUT DR. BERG: http://www.drberg.com/dr-eric-berg/bio DR. BERG'S SEMINARS: http://www.drberg.com/seminars DR. BERG'S STORY: http://www.drberg.com/dr-eric-berg/story DR. BERG'S CLINIC: https://www.drberg.com/dr-eric-berg/c... DR. BERG'S HEALTH COACHING TRAINING: http://www.drberg.com/weight-loss-coach DR. BERG'S SHOP: http://shop.drberg.com/ DR. BERG'S REVIEWS: http://www.drberg.com/reviews The Health & Wellness Center 4709 D Pinecrest Office Park Drive Alexandria, VA 22312 703-354-7336 Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.
Views: 553596 Dr. Eric Berg DC
Do you have to take cholestyramine with food
 
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Do you have to take cholestyramine with food - Find out more explanation for : 'Do you have to take cholestyramine with food' only from this channel. Information Source: google
Views: 16 el ubuntu3
My Biotoxin Illness Treatment -- The Beginning
 
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I created this video to explain some of my medical history and continuing struggles that have resulted in a precise diagnosis of biotoxin illness. I will commence treatment with a specialist who will get the ball rolling in our first appointment on March 23, 2016. I am requesting support at https://www.gofundme.com/z6uhtc9b. Depending upon the responses to this video, I may post updates about my treatment for those who are interested in biotoxin illness, which is a largely undiagnosed but likely common illness. Our bodies are not superhuman to perfectly handle the plethora of microorganisms around and inside of us. Awareness and proper treatment is key toward success. I am putting myself out there for your support as well as my supporting you if you have similar chronic symptoms that have been largely dismissed by the medical community. I had a poor health day while making this video, so I was more uncomfortable talking about the illnesses than usual because it's not easy to stay strong when focusing on weakness. It's a mental balance that needs to be maintained in order to function, because focusing on being "sick" can bring about a feeling of helplessness and despair. I'm sure other chronically ill people can relate. We just do the best we can in any given moment.
Views: 2103 Theresa Talea
Hypolipidemic Agents
 
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This is a brief overview of hypolipidemic agents, or drugs that alter the levels of lipids in the body. I created this presentation with Google Slides. Image were created or taken from Wikimedia Commons I created this video with the YouTube Video Editor. ADDITIONAL TAGS Hypolipidemic Agents Statins Bile Acid Sequestrants Niacin Fibrates Statins Inhibit the enzyme HMG-CoA reductase, which is the rate limiting step in cholesterol synthesis Decrease LDL, increase HDL, decrease TGs Proven to reduce risk of coronary artery disease Side effects: Liver toxicity (most metabolized by cytochrome P450), muscle toxicity (rhabdomyolysis) Contraindications: liver disease, CYP450 inhibitor drugs, pregnancy (birth defects) Lovastatin, Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin Statins Bile Acid Sequestrants Niacin Fibrates Bile Acid Sequestrants Binds bile acid in the gut and prevents reuptake, thus promoting excretion of bile acid Cholesterol is typically converted to bile acid and secreted into the GI tract; 99% of this bile acid is then reabsorbed into the body Loss of 1% of bile acid is typically the only method of removing cholesterol from the body Bile acid sequestrants allow for more than 1% of bile acid to excreted from the body, forcing body to produce more bile acid from cholesterol Decrease LDL, increase HDL, no effect on TGs Side effects: GI distress (nausea, constipation, bloating → since it’s inhibiting fat absorption, resolved with fiber intake) Malabsorption of other drugs and fat-soluble vitamins (DEAK) Avoid use in people with familial dysbetalipoproteinemia with very high TG Colestipol (Colestid), Colesevelam (Welchol), Cholestyramine (Questran) Statins Bile Acid Sequestrants Niacin Fibrates Niacin Prevents release of free fatty acid into the bloodstream from adipocytes Increases HDL by decreasing hepatic excretion of a major protein in HDL (apoA-I) Increase HDL, decreases LDL, decreases TGs Side effects: skin flushing (resolved with aspirin), hyperuremia, hyperglycemia, GI distress (n/v and peptic ulcers), and hepatotoxicity Contraindications: patients with gout and liver disease (monitor liver enzymes) Niacin (Niaspan, Niacor) is also known as nicotinic acid or vitamin B3 Niacin has a number of other functions, and lack of niacin causes pellagra, degenerative disease causing skin lesions (shown) and mental disturbance Statins Bile Acid Sequestrants Niacin Fibrates Fibrates Activate a transcription factor (peroxisome proliferator-activated receptors (PPARs)) that increases lipoprotein lipase, which converts VLDL to LDL and therefore reduces VLDL and triglyceride levels PPARs are regulators that transport from cytoplasm to nucleus to bind regulatory regions of target genes Decrease TGs, decrease LDL, increase HDL Side effects: GI distress, skin rash, muscle toxicity (also worsened by statins, too), hypokalemia, arrhythmias Avoid use in patients with liver and renal disease Gemfibrozil Fenofibrate Statins Bile Acid Sequestrants Niacin Fibrates
Views: 10521 MedLecturesMadeEasy
USMLE Cardiovascular 9: Atherosclerosis, Arteriosclerosis, and Hyperlipidemia Pharmacology
 
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Welcome to LY Med, where I go over everything you need to know for the USMLE STEP 1, with new videos every day. Follow along with First Aid, or with my notes which can be found here: https://www.dropbox.com/sh/xisbr5u8reifaqk/AAAEWF-Ho2r0OJMooCYN_bG-a?dl=0 So in our previous video, we discussed some complications of high blood pressure, (HTN - hypertension). We will continue that discussion today with a talk about arteriosclerosis and atherosclerosis. Arteriosclerosis: this is sclerosis of your arterioles. You have different types, like hyaline and hyperplastic. Hyperplastic arteriosclerosis stems from smooth muscle proliferation that reinforces the wall and looks like onion skinning. Grossly, there are microscopic hemorrhages that make the kidneys look flea bitten. The last type is Mockenberg sclerosis which is due to calcification of the medial layer and this can be seen on xray. This doesn't effect the lumen! Atherosclerosis: this is due to cholesterol plaques. How do we form these plaques? Well high blood pressure can cause intima tears and LDL can enter underneath the vessels. Macrophages come in and eat the LDL and die as foam cells. This causes a fatty streak. Platelets will hit this fatty streak and release platelet derived growth factors which recruit smooth muscles up to the intima and those smooth muscles will release fibrous proteins that create a cap over the fatty streak. This ultimately results in a cholesterol plaque - the fatty streak and the cap. That's atherosclerosis! There are many complications of this plaque. It can rupture and lead to thrombosis or embolisms with cholesterol clefts. The most common location of atherosclerosis is the abdominal aorta, then coronary arteries, popliteal and finally carotids. Risk factors include high BP, smoking, diabetes (DM) and increased LDL. Our last topic will be on hyperlipidemia and drugs that combat this. Just a recap, we transport fat and cholesterol to our liver and to our body via lipoproteins like chylomicrons, vldl, idl, LDL, and HDL. Your liver needs cholesterol for daily function and to make bile. Our liver can make cholesterol if it's low via HMG Coa reductase. It can also send that cholesterol to our body and lipases pull fat from these transporters. HDL transports excess fat back to the liver. Therefore we call HDL good cholesterol and LDL bad cholesterol. Let's talk about some pharmacology. Some drugs you should know is : 1) Statins (Hmg-coa reductase inhibitors): this blocks the rate limiting enzyme for making cholesterol, leading to hepatotoxicity and myopathy. Monitor LFT and CK! 2) Ezetimibe: this blocks the reabsorption of fat in the gut. 3) Bile acid resins (cholestyramine): this blocks the reabsorption of bile acids in the ileum and your liver will use cholesterol to make more instead of sending it out. Side effects is fat malabsorption. 4) Fibrates: This works on genes that modulate fat metabolism via the PPARa gene. Side effects include myopathy so avoid with statins! 5) Niacin: this is vitamin B3! This inhibits hormone sensitive lipase and side effects include hyperglycemia, hyper uric acid leading to gout and flushing from prostaglandins. Relieve this with NSAIDS!
Views: 1425 LY Med
Statins and Memory Loss? Forget About It
 
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http://www.dailyrxnews.com/statins-did-not-appear-cause-memory-loss One lifesaving drug may have even fewer side effects than previously thought. A new study found that, contrary to previous reports, statins were not likely a cause of memory loss. “People who have high cholesterol should be on statins,” said lead study author Brian L. Strom, MD, chancellor of Rutgers Biomedical and Health Sciences, in a press release. “People shouldn't steer away from the drug because of false fear of memory problems." About 1 in 4 deaths in the US are caused by heart disease, according to Dr. Strom and team. Statins, such as atorvastatin (brand name Lipitor) or rosuvastatin (Crestor), are commonly prescribed to reduce this risk. Statins are a class of drugs that lower cholesterol. Dr. Strom and team looked at the link between statins and memory loss. These researchers compared 482,542 patients taking statins to 482,543 patients who weren’t on statins. About 5 percent of the second group were taking nonstatin cholesterol-lowering drugs, such as cholestyramine (brand name Prevalite). Dr. Strom and team found that most of the patients in the first group reported some memory loss during the first 30 days of taking statins. However, most of the patients taking nonstatins also reported memory loss. These findings suggest that these drugs may not actually cause memory loss — but rather may lead to a “detection bias." In other words, patients may be more likely to notice existing memory issues when they start taking a new drug — because they are more focused on their health, Dr. Strom and team said. “When patients are put on statins or any new drug, they’re seen more often by their doctor, or they themselves are paying attention to whether anything is wrong,” Dr. Strom said. “So if they have a memory problem, they’re going to notice it. Even if it has nothing to do with the drug, they’re going to blame it on the drug."
Views: 688 dailyRx
A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid...
 
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Dr. Julian Walters discusses his manuscript "A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis." To view the print version of this abstract go to: http://tiny.cc/cm6u0
Views: 7549 AmerGastroAssn
How Long Does It Take To Get Metamucil Out Of Your System?
 
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Longbad cholesterol 28 oct 2014 psyllium (metamucil) is used for treating constipation and may also before taking metamucil, you should tell your doctor if have a this dose can be taken up to three times day powdered drink are scheduled doses of take the missed as soon remember i'd taper off metamucil see it makes any difference. Metamucil which is better for me? Healthline. Metamucil frequently asked questions metamucil uses, side effects & warnings drugs. Nutrition content 71 2 472. Doctor before i take metamucil to lower cholesterol or maintain healthy blood sugar levels? Any time of day is appropriate as long an adequate intake fluids these ingredients may be concern if you have diabetes, high psyllium can swell in your throat and cause choking don't it with enough liquid. It takes a few days to get your system used metamucil you have take it slow and start out with small amount titrate up the like being cause of negative side effects, long term success may be limited. I now have really bad diarrhea the metamucil finally coming out? It feels good to get waste out of my system has been doctor recommended go fiber supplement for decades, i would just like point before on, that most products, alternatives available don't long list 'non active' ingredients. Metamucil frequently asked questions. Metamucil and cholesterol is there a connection? Healthline. Laxatives may be habit forming if they are used too often or for long. Metamucil & bloating totally new to this and would love some real info question about metamucil. The thought of drinking that gritty stuff still grosses me out. Do not stop taking this medication without consulting your doctor. Is metamucil safe? The truth behind this 'doctor recommended bowel disorders message board anyone taking to stay regular during pregnancy benefiber vs. Metamucil psyllium fibre belongs to two groups of medications bulk forming laxatives acids, cholesterol levels in the blood are reduced when more bile acid is made. The nightmare a good indicator with metamucil is getting your poop to float. Bloating is a common side effect when you start taking metamucil hello, i apologize if this gets long. You can take benefiber or metamucil up to three times per day, but you find out how much fiber need, where get it, and the best way 26 oct 2015 help lower my total cholesterol? To feel fuller between meals maintain blood sugar levels. Cholestyramine questran questions irritable bowel syndrome how to do colon cleanse using metamucil or psyllium uses, side effects, interactions canoe. Psyllium (metamucil) side effects, dosage, interactions drugs. If you have 2 3 weeks can take time to practice subbing as well metamucil redirects the body fat with thc towards stools where 75. Metamucil & bloating totally new to this and would love some real info question about metamucilMetamucil review fiber, regularity weight loss? . I'm 42 and i have had ibs for as long can remember. Does metamucil lower ldl cholesterol? . To harm my
Views: 874 Wen Wen
Biotoxin Illness 101: Part III
 
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In part 3 of this installment, Dr. Ritchie Shoemaker speaks about various biotoxin related illnesses such as Chronic Fatigue Syndrome, Fibromyalgia, Lyme Disease and Mold. More available at www.biotoxin.info Why Haven't I Ever Heard of Biotoxins & Biotoxin Illness Before? You probably have heard of it, only it was called something else like Chronic Fatigue Syndrome (CFIDS), Fibromyalgia, Chronic Lyme Disease (CLD), Mold Illness, or ADHD (see "Other Names for Biotoxin Illness" below). The discoveries and the science behind how biotoxins are involved in these illnesses and disorders is fairly new. Ritchie Shoemaker, MD presented some of our most recent Chronic Fatigue research and treatment findings at The International Association for Chronic Fatigue Syndrome conference held in Fort Lauderdale, Florida in January of 2007. We have also just completed a soon to be published ground-breaking study on the health effects of mold exposure. Many progressive doctors around the country endorse the use of our on-line test and the cholestyramine-based treatment protocol pioneered by Ritchie Shoemaker, MD. Remember though, that medical advances are ultimately driven through peer-reviewed publication in medical journals. These studies are expensive and time consuming and our recent peer-reviewed publications will help advance these discoveries into mainstream medicine. Soon many more doctors will be aware of biotoxins and the role they play in chronic illness. That said, many leading experts in mold exposure, chronic fatigue, fibromyalgia and Acute or Chronic Lyme Disease (CLD) are familiar with, and use our screening test and cholestyramine protocol. For example, Dr. Jacob Teitelbaum, Chief Medical Officer of the Fibro and Fatigue Center Clinics, has included a chapter on Dr. Ritchie Shoemaker's biotoxin discoveries and how they relate to CFIDS and Fibroymylgia in the updated revision of his book titled From Fatigued to Fantastic!, which was published in 2007. Additionally, Dr. Shoemaker testified about the human health effects of mold exposure for the US Congress in January of 2006.
Views: 6721 biotoxin1
Cholestagel (colesevelam) Tablets
 
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Cholestagel tablets contain the active ingredient colesevelam, which is a type of medicine called a bile acid sequestrant. It is used to lower blood cholesterol levels.
Views: 81 Lynch's Pharmacy
New #6 Cholesterol Drug Dangers
 
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Frank Cooper, Naturopath and Nutritionist, is the author of the book 'Cholesterol and The French Paradox' written for patients with high cholesterol. He has university qualifications in complementary medicine and microbiology, and is qualified to practice as a Naturopath (ND) and as a Nutritionist in Australia. Over the past 10 years he has undertaken research in the area of environmental medicine that studies the alignment of our environment (food, water, chemicals, microbes) with chronic disease states including cancer, heart disease and diabetes. Frank is the author of the book Cholesterol and The French Paradox available from www.amazon.com that explains why only 10% of those taking statins (cholesterol-lowering medications) actually derive any benefit, whilst the other 90% gain no benefit at all, but are 'at risk' of liver toxicity and damage, muscle damage, and worst of all -- irreversible mental cognitive impairment.
Views: 1077 Frank Cooper
Home Remedies for High Cholesterol – Natural and Ayurvedic
 
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Natural Ayurvedic Home Remedies for High Cholesterol. For More Health Tips, Beauty Tips and Home Remedies Visit: http://health.a2ztube.co Home Remedies for High Cholesterol • Orange • Watermelon Seed Powder and Water. • Gooseberry Powder and Water. • Coriander Seed Powder and Water. • Onions and Honey. • Water, Basil and Margosa Leaves • Green Tea. • Almonds and Walnuts. • Cinnamon, Water and Honey. • Apple Cider Vinegar and Water. Health Disclaimer The Information on this channel is designed for educational purpose only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health problems. PLEASE CONSULT A DOCTOR WITH ANY QUESTIONS OR CONCERNS a2ztube warrants that the content in this video is provided on an "as is" basis with no express or implied warranties whatsoever. Any reference of any third party logos, brand names, trademarks, services marks, trade names, trade dress and copyrights shall not imply any affiliation to such third parties, unless expressly specified. Thank you for watching. | Natural Remedies for High Cholesterol You Might Be Interested in Checking Out few of Our Other Websites. Watch Movies: http://music.a2ztube.co Watch TV Shows: http://tv.a2ztube.co Music Albums: http://music.a2ztube.co Tutorials: http://edu.a2ztube.co Visit our channels | Hypercholesterolemia - Herbal Cure http://www.youtube.com/user/a2ztutorial http://www.youtube.com/user/a2zguide Subscribe to stay updated: http://www.youtube.com/subscription_center?add_user=a2ztutorial http://www.youtube.com/subscription_center?add_user=a2zguide Join Us on Facebook: https://www.facebook.com/a2ztube Follow Us on Twitter: https://twitter.com/a2ztube Audio Credits: | Ayurvedic Remedies for Hypercholesterolemia http://www.Machinimasound.com Jason Farnham (Locally Sourced) – YouTube Audio Library http://www.jasonfarnham.com/ Riot (Safety Net) – YouTube Audio Library Image Credits Image courtesy of [photofriday] at FreeDigitalPhotos.net Image courtesy of [winnond] at FreeDigitalPhotos.net Image courtesy of [bplanet] at FreeDigitalPhotos.net Image courtesy of [vudhikrai] at FreeDigitalPhotos.net Image courtesy of [SOMMAI] at FreeDigitalPhotos.net Image courtesy of [Stuart Miles] at FreeDigitalPhotos.net Pixabay.com FreeImages.com
Atorvastatin Pharmacology Video
 
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Video made by Kelli, Alex, and Megan.
Views: 203 Alex Scobee